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Lack of sleep can cause:

  1. Decreased appetite

  2. Fatigue

  3. Increased confusion

  4. Increased irritability

The correct answer is: Decreased appetite

Lack of sleep can cause fatigue, increased confusion, and increased irritability. However, decreased appetite is the answer as it is common to experience a loss of appetite when not getting enough sleep. This is due to the fact that the hormones that regulate hunger and fullness can be disrupted by lack of sleep, leading to reduced appetite. Additionally, when we are sleep-deprived, our body may produce more ghrelin, a hormone that stimulates appetite, and less leptin, a hormone that suppresses appetite. So, while the other options may also be effects of lack of sleep, decreased appetite is the most direct and correct answer.