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Normal age-related changes for the endocrine system include the following:

  1. Decrease in levels of hormones signal the onset of menopause in women

  2. Increase in levels of hormones in the bloodstream

  3. Maintaining constant hormone levels throughout life

  4. Stability in glucose metabolism without changes

The correct answer is: Decrease in levels of hormones signal the onset of menopause in women

The correct choice highlights the decrease in hormone levels that signal the onset of menopause in women, a well-documented normal age-related change in the endocrine system. As women age, particularly during the transition into menopause, the production of key hormones, such as estrogen and progesterone, typically declines. This change can lead to various symptoms associated with menopause and reflects the natural aging process of the endocrine system, illustrating how hormonal fluctuations are a normal part of aging. In contrast, the other options reflect misconceptions about age-related changes. An increase in hormone levels in the bloodstream is not typically observed; rather, many hormone levels often decrease or fluctuate with age. Maintaining constant hormone levels throughout life does not occur, as hormonal balance can shift due to various factors including age, health status, and lifestyle. Stability in glucose metabolism is also misleading; glucose metabolism can be affected by age-related changes, leading to insulin resistance or other metabolic issues. Thus, the first statement accurately conveys a significant normal change in the endocrine system with aging.